The one hundred and ninth comic: #30 Barney Google & Snuffy Smith
The early comics list, as a result of the development of the medium, is dominated by newspaper strips. Barney Google is one of those that survived for over a century, although it shifted what it was about in a way that made it almost unfamiliar. The original are (by now) overdone gags based around Barney Google, with a lot of relationship jokes at first but evolving away from that. Snuffy Smith came in years later, but started to dominate the strip, as it became more of a yokel story set in the boonies, with the original character barely showing up. The hillbilly humour is even further removed from what I care for, and it feels like such a relic looking at it now, without moving much after the earlier larger shifts.
The one hundred and tenth comic: #347 Hagar the Horrible
In contrast, Hagar the Horrible comes in from a similiar angle, especially Barney Google's earlier city life, The daily gag strips aren't the best - again, there are a lot of known jokes, with the setting making it a bit more interesting as a contrast to the modern world. It's the longer stories that are more interesting, which there have been a few of from what I can tell. There's a lot of room for references, bu tthe longer format really helps set up the additional context for the humour.