The twelfth TV show: #652 Venture Bros
Having regularly watched Archer (which will come up at some point in the future), the basics of adult animation are familiar to me. Venture Bros seems to be an early one introduced by Cartoon Network, at least of its 'generation'. Taking on the adventure animation stories from the past - Johnny Quest a clear inspiration, but the likes of Scooby Doo also present.
It's semi-serialized, individual adventures in a plotline. It quicly creates its own cast that expands beyond the Venture familiy, that gets referenced and returns whenever possible and plausible. What seem like one-joke characters quickly get their own longer storylines, creating a nice but messed up world.
One with a surprising amount of cartoon nudity. Somehow.