The fifty-second comic: #574 Frank
Here's the first comic listed as being 'funny animal', although we've seen parodies of the genre before while I suppose the likes of Garfield are just humor comics. Here it's a longer story, several pages of this strange animal (vaguely cat-like) called Frank who lives in this bizarre world. Frank has a small house-shaped pet and meets several other bizarre creatures hwo live in this world. Some of these are colourful (when applicable) nightmare creatures of strange designs, who are probably the most visually stunning parts, but in the end it's all down to these small adventures and encounters in the world, even when they involve plucking weird creatures out of the sky.