The ninety-fourth comic: #869 We3
There's something fully uncomfortable about reading We3. This story, about three animals turned into cyborgs to function as half-robotic weapons, starts off with orders for their destruction. Only barely understanding what's going on, they escape and roam the countryside as they try to defend themselves against those trying to capture and kill them. There's a lot of action in here, but the comic's focus is its sadness, with pets who were trying to please their owners being chased and not understanding. The fact that you can see them deteriorate as they do so, while they miss the medicine needed to keep them alive with their implants, emphasizes that further and they keep looking worse. It's an upsetting and brutal story, which builds a lot of pathos for creatures who can barely communicate even with what you see - recognisable and moving, with a dark art style to match.